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Intracellular Na(+) Concentration ([Na(+)](i)) Is Elevated in Diabetic Hearts Due to Enhanced Na(+)–Glucose Cotransport
BACKGROUND: Intracellular Na(+) concentration ([Na(+)](i)) regulates Ca(2+) cycling, contractility, metabolism, and electrical stability of the heart. [Na(+)](i) is elevated in heart failure, leading to arrhythmias and oxidative stress. We hypothesized that myocyte [Na(+)](i) is also increased in ty...
Autores principales: | Lambert, Rebekah, Srodulski, Sarah, Peng, Xiaoli, Margulies, Kenneth B, Despa, Florin, Despa, Sanda |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley & Sons, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599504/ https://www.ncbi.nlm.nih.gov/pubmed/26316524 http://dx.doi.org/10.1161/JAHA.115.002183 |
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