VPS35 pathogenic mutations confer no dominant toxicity but partial loss of function in Drosophila and genetically interact with parkin

Mutations in VPS35 (PARK17) cause autosomal dominant, late onset Parkinson's disease (PD). VPS35 forms a core component of the retromer complex that mediates the retrieval of membrane proteins from endosomes back to either the Golgi or plasma membrane. While aberrant endosomal protein sorting h...

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Detalles Bibliográficos
Autores principales: Malik, Bilal R., Godena, Vinay K., Whitworth, Alexander J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599670/
https://www.ncbi.nlm.nih.gov/pubmed/26251041
http://dx.doi.org/10.1093/hmg/ddv322

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599670/
https://www.ncbi.nlm.nih.gov/pubmed/26251041
http://dx.doi.org/10.1093/hmg/ddv322

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