Improvement of in vivo efficacy of recombinant human erythropoietin by encapsulation in PEG–PLA micelle

To improve the pharmacokinetics and stability of recombinant human erythropoietin (rhEPO), rhEPO was successfully formulated into poly(ethylene glycol)–poly(d,l-lactide) (PEG–PLA) di-block copolymeric micelles at diameters ranging from 60 to 200 nm with narrow polydispersity indices (PDIs; PDI <...

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Detalles Bibliográficos
Autores principales: Shi, Yanan, Huang, Wan, Liang, Rongcai, Sun, Kaoxiang, Zhang, Fangxi, Liu, Wanhui, Li, Youxin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2012
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599715/
https://www.ncbi.nlm.nih.gov/pubmed/23293515
http://dx.doi.org/10.2147/IJN.S38648

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599715/
https://www.ncbi.nlm.nih.gov/pubmed/23293515
http://dx.doi.org/10.2147/IJN.S38648

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