A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions

We present a novel strategy to identify drug-repositioning opportunities. The starting point of our method is the generation of a signature summarising the consensual transcriptional response of multiple human cell lines to a compound of interest (namely the seed compound). This signature can be der...

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Detalles Bibliográficos
Autores principales: Iorio, Francesco, Shrestha, Roshan L., Levin, Nicolas, Boilot, Viviane, Garnett, Mathew J., Saez-Rodriguez, Julio, Draviam, Viji M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599732/
https://www.ncbi.nlm.nih.gov/pubmed/26452147
http://dx.doi.org/10.1371/journal.pone.0139446

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599732/
https://www.ncbi.nlm.nih.gov/pubmed/26452147
http://dx.doi.org/10.1371/journal.pone.0139446

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