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A Semi-Supervised Approach for Refining Transcriptional Signatures of Drug Response and Repositioning Predictions
We present a novel strategy to identify drug-repositioning opportunities. The starting point of our method is the generation of a signature summarising the consensual transcriptional response of multiple human cell lines to a compound of interest (namely the seed compound). This signature can be der...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599732/ https://www.ncbi.nlm.nih.gov/pubmed/26452147 http://dx.doi.org/10.1371/journal.pone.0139446 |