Expression screening using a Medaka cDNA library identifies evolutionarily conserved regulators of the p53/Mdm2 pathway

BACKGROUND: The p53 tumor suppressor protein is mainly regulated by alterations in the half-life of the protein, resulting in significant differences in p53 protein levels in cells. The major regulator of this process is Mdm2, which ubiquitinates p53 and targets it for proteasomal degradation. This...

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Detalles Bibliográficos
Autores principales: Zhang, Ping, Kratz, Anne Sophie, Salama, Mohammed, Elabd, Seham, Heinrich, Thorsten, Wittbrodt, Joachim, Blattner, Christine, Davidson, Gary
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599741/
https://www.ncbi.nlm.nih.gov/pubmed/26450685
http://dx.doi.org/10.1186/s12896-015-0208-y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599741/
https://www.ncbi.nlm.nih.gov/pubmed/26450685
http://dx.doi.org/10.1186/s12896-015-0208-y

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