The chemical chaperone sodium 4-phenylbutyrate improves the secretion of the protein C(A267T) mutant in CHO-K1 cells trough the GRASP55 pathway

Some inherited coagulation factor deficiencies are caused by intracellular retention or degradation of misfolded proteins, and chemical chaperones have been shown to reverse protein misfolding. The purpose of the present study was to investigate whether chemical chaperones may improve secretion of t...

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Detalles Bibliográficos
Autores principales: Chollet, Maria Eugenia, Skarpen, Ellen, Iversen, Nina, Sandset, Per Morten, Skretting, Grethe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599753/
https://www.ncbi.nlm.nih.gov/pubmed/26457178
http://dx.doi.org/10.1186/s13578-015-0048-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599753/
https://www.ncbi.nlm.nih.gov/pubmed/26457178
http://dx.doi.org/10.1186/s13578-015-0048-4

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