Concomitant histone deacetylase and phosphodiesterase 5 inhibition synergistically prevents the disruption in synaptic plasticity and it reverses cognitive impairment in a mouse model of Alzheimer’s disease

BACKGROUND: Given the implication of histone acetylation in memory processes, histone deacetylase inhibitors (HDACIs) have been postulated as potential modulators of cognitive impairment in Alzheimer’s disease (AD). However, dose-dependent side effects have been described in patients with the curren...

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Detalles Bibliográficos
Autores principales: Cuadrado-Tejedor, M., Garcia-Barroso, C., Sanzhez-Arias, J., Mederos, S., Rabal, O., Ugarte, A., Franco, R., Pascual-Lucas, M., Segura, V., Perea, G., Oyarzabal, J., Garcia-Osta, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599811/
https://www.ncbi.nlm.nih.gov/pubmed/26457123
http://dx.doi.org/10.1186/s13148-015-0142-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599811/
https://www.ncbi.nlm.nih.gov/pubmed/26457123
http://dx.doi.org/10.1186/s13148-015-0142-9

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