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Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross

New systems genetics approaches are needed to rapidly identify host genes and genetic networks that regulate complex disease outcomes. Using genetically diverse animals from incipient lines of the Collaborative Cross mouse panel, we demonstrate a greatly expanded range of phenotypes relative to clas...

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Detalles Bibliográficos
Autores principales: Gralinski, Lisa E., Ferris, Martin T., Aylor, David L., Whitmore, Alan C., Green, Richard, Frieman, Matthew B., Deming, Damon, Menachery, Vineet D., Miller, Darla R., Buus, Ryan J., Bell, Timothy A., Churchill, Gary A., Threadgill, David W., Katze, Michael G., McMillan, Leonard, Valdar, William, Heise, Mark T., Pardo-Manuel de Villena, Fernando, Baric, Ralph S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599853/
https://www.ncbi.nlm.nih.gov/pubmed/26452100
http://dx.doi.org/10.1371/journal.pgen.1005504