Wild-Type Hras Suppresses the Earliest Stages of Tumorigenesis in a Genetically Engineered Mouse Model of Pancreatic Cancer

Oncogenic, activating mutations in KRAS initiate pancreatic cancer. There are, however, two other Ras family members, Nras and Hras, which can be activated in the presence of oncogenic Kras. The role of these wild-type Ras proteins in cancer remains unclear, as their disruption has been shown to enh...

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Detalles Bibliográficos
Autores principales: Weyandt, Jamie D., Lampson, Benjamin L., Tang, Sherry, Mastrodomenico, Matthew, Cardona, Diana M., Counter, Christopher M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599940/
https://www.ncbi.nlm.nih.gov/pubmed/26452271
http://dx.doi.org/10.1371/journal.pone.0140253

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4599940/
https://www.ncbi.nlm.nih.gov/pubmed/26452271
http://dx.doi.org/10.1371/journal.pone.0140253

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