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Increased susceptibility of CD4+ T cells from elderly individuals to HIV-1 infection and apoptosis is associated with reduced CD4 and enhanced CXCR4 and FAS surface expression levels
BACKGROUND: Elderly HIV-1 infected individuals progress to AIDS more frequently and rapidly than people becoming infected at a young age. To identify possible reasons for these differences in clinical progression, we performed comprehensive phenotypic analyses of CD4+ T cells from uninfected young a...
Autores principales: | Heigele, Anke, Joas, Simone, Regensburger, Kerstin, Kirchhoff, Frank |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600300/ https://www.ncbi.nlm.nih.gov/pubmed/26452480 http://dx.doi.org/10.1186/s12977-015-0213-1 |
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