Vascular, but not luminal, activation of FFAR1 (GPR40) stimulates GLP-1 secretion from isolated perfused rat small intestine

Glucagon-like peptide 1 (GLP-1) plays a central role in modern treatment of type 2 diabetes (T2DM) in the form of GLP-1 enhancers and GLP-1 mimetics. An alternative treatment strategy is to stimulate endogenous GLP-1 secretion from enteroendocrine L cells using a targeted approach. The G-protein-cou...

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Detalles Bibliográficos
Autores principales: Christensen, Louise W, Kuhre, Rune E, Janus, Charlotte, Svendsen, Berit, Holst, Jens J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600392/
https://www.ncbi.nlm.nih.gov/pubmed/26381015
http://dx.doi.org/10.14814/phy2.12551

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600392/
https://www.ncbi.nlm.nih.gov/pubmed/26381015
http://dx.doi.org/10.14814/phy2.12551

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