Effects of decreased lactate accumulation after dichloroacetate administration on exercise training–induced mitochondrial adaptations in mouse skeletal muscle

Recent studies suggested that lactate accumulation can be a signal for mitochondrial biogenesis in skeletal muscle. We investigated whether reductions in lactate concentrations in response to dichloroacetate (DCA), an activator of pyruvate dehydrogenase, attenuate mitochondrial adaptations after exe...

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Detalles Bibliográficos
Autores principales: Hoshino, Daisuke, Tamura, Yuki, Masuda, Hiroyuki, Matsunaga, Yutaka, Hatta, Hideo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600395/
https://www.ncbi.nlm.nih.gov/pubmed/26416973
http://dx.doi.org/10.14814/phy2.12555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600395/
https://www.ncbi.nlm.nih.gov/pubmed/26416973
http://dx.doi.org/10.14814/phy2.12555

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