Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice

In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated. BALB/c mice (n = 60; 4–6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control....

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Autores principales: Stakisaitis, Donatas, Mozuraite, Raminta, Juodziukyniene, Nomeda, Didziapetriene, Janina, Uleckiene, Saule, Matusevicius, Paulius, Valanciute, Angelija
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600510/
https://www.ncbi.nlm.nih.gov/pubmed/26491438
http://dx.doi.org/10.1155/2015/218219
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author Stakisaitis, Donatas
Mozuraite, Raminta
Juodziukyniene, Nomeda
Didziapetriene, Janina
Uleckiene, Saule
Matusevicius, Paulius
Valanciute, Angelija
author_facet Stakisaitis, Donatas
Mozuraite, Raminta
Juodziukyniene, Nomeda
Didziapetriene, Janina
Uleckiene, Saule
Matusevicius, Paulius
Valanciute, Angelija
author_sort Stakisaitis, Donatas
collection PubMed
description In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated. BALB/c mice (n = 60; 4–6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control. In the same groups, ovariectomized female mice (n = 60) were investigated. Urethane was given intraperitoneally, with a total dose of 50 mg/mouse. In NaVP-treated mice groups, 0.4% aqueous solution of NaVP was offered to mice ad libitum. The duration of the experiment was 6 months. The number of tumors per mouse in ovariectomized mice and in those treated with urethane and NaVP was significantly higher than in mice treated with urethane only (8.29 ± 0.58 versus 6.0 ± 0.63, p < 0.02). No significant difference in the number of tumors per mouse was revealed while comparing the nonovariectomized urethane- and urethane-NaVP-treated groups (p = 0.13). A significant decrease of adenocarcinoma number in ovariectomized mice treated with a urethane-NaVP as compared with ovariectomized mice treated with urethane only was found (p = 0.031). NaVP together with low estrogen may have a protective effect on the malignization of adenomas in ovariectomized mice.
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spelling pubmed-46005102015-10-21 Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice Stakisaitis, Donatas Mozuraite, Raminta Juodziukyniene, Nomeda Didziapetriene, Janina Uleckiene, Saule Matusevicius, Paulius Valanciute, Angelija Int J Endocrinol Research Article In the present study, the possible effect of sodium valproate (NaVP) on urethane-induced lung tumors in female mice has been evaluated. BALB/c mice (n = 60; 4–6 weeks old, females) were used in the following groups: (1) urethane-treated; (2) urethane-NaVP-treated; (3) only NaVP-treated; (4) control. In the same groups, ovariectomized female mice (n = 60) were investigated. Urethane was given intraperitoneally, with a total dose of 50 mg/mouse. In NaVP-treated mice groups, 0.4% aqueous solution of NaVP was offered to mice ad libitum. The duration of the experiment was 6 months. The number of tumors per mouse in ovariectomized mice and in those treated with urethane and NaVP was significantly higher than in mice treated with urethane only (8.29 ± 0.58 versus 6.0 ± 0.63, p < 0.02). No significant difference in the number of tumors per mouse was revealed while comparing the nonovariectomized urethane- and urethane-NaVP-treated groups (p = 0.13). A significant decrease of adenocarcinoma number in ovariectomized mice treated with a urethane-NaVP as compared with ovariectomized mice treated with urethane only was found (p = 0.031). NaVP together with low estrogen may have a protective effect on the malignization of adenomas in ovariectomized mice. Hindawi Publishing Corporation 2015 2015-09-27 /pmc/articles/PMC4600510/ /pubmed/26491438 http://dx.doi.org/10.1155/2015/218219 Text en Copyright © 2015 Donatas Stakisaitis et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Stakisaitis, Donatas
Mozuraite, Raminta
Juodziukyniene, Nomeda
Didziapetriene, Janina
Uleckiene, Saule
Matusevicius, Paulius
Valanciute, Angelija
Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
title Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
title_full Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
title_fullStr Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
title_full_unstemmed Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
title_short Sodium Valproate Enhances the Urethane-Induced Lung Adenomas and Suppresses Malignization of Adenomas in Ovariectomized Female Mice
title_sort sodium valproate enhances the urethane-induced lung adenomas and suppresses malignization of adenomas in ovariectomized female mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600510/
https://www.ncbi.nlm.nih.gov/pubmed/26491438
http://dx.doi.org/10.1155/2015/218219
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