Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries

Broadly neutralizing antibodies developed from the IGHV1–69 germline gene are known to bind to the stem region of hemagglutinin in diverse influenza viruses but the sequence determinants for the antigen recognition, including neutralization potency and binding affinity, are not clearly understood. S...

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Detalles Bibliográficos
Autores principales: Tung, Chao-Ping, Chen, Ing-Chien, Yu, Chung-Ming, Peng, Hung-Pin, Jian, Jhih-Wei, Ma, Shiou-Hwa, Lee, Yu-Ching, Jan, Jia-Tsrong, Yang, An-Suei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601012/
https://www.ncbi.nlm.nih.gov/pubmed/26456860
http://dx.doi.org/10.1038/srep15053

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601012/
https://www.ncbi.nlm.nih.gov/pubmed/26456860
http://dx.doi.org/10.1038/srep15053

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