Specific binding of eukaryotic ORC to DNA replication origins depends on highly conserved basic residues

In eukaryotes, the origin recognition complex (ORC) heterohexamer preferentially binds replication origins to trigger initiation of DNA replication. Crystallographic studies using eubacterial and archaeal ORC orthologs suggested that eukaryotic ORC may bind to origin DNA via putative winged-helix DN...

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Detalles Bibliográficos
Autores principales: Kawakami, Hironori, Ohashi, Eiji, Kanamoto, Shota, Tsurimoto, Toshiki, Katayama, Tsutomu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601075/
https://www.ncbi.nlm.nih.gov/pubmed/26456755
http://dx.doi.org/10.1038/srep14929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601075/
https://www.ncbi.nlm.nih.gov/pubmed/26456755
http://dx.doi.org/10.1038/srep14929

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