Mice lacking GPR3 receptors display late-onset obese phenotype due to impaired thermogenic function in brown adipose tissue

We report an unexpected link between aging, thermogenesis and weight gain via the orphan G protein-coupled receptor GPR3. Mice lacking GPR3 and maintained on normal chow had similar body weights during their first 5 months of life, but gained considerably more weight thereafter and displayed reduced...

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Detalles Bibliográficos
Autores principales: Godlewski, Grzegorz, Jourdan, Tony, Szanda, Gergő, Tam, Joseph, Resat Cinar, Harvey-White, Judith, Liu, Jie, Mukhopadhyay, Bani, Pacher, Pál, Ming Mo, Fong, Osei-Hyiaman, Douglas, George Kunos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601089/
https://www.ncbi.nlm.nih.gov/pubmed/26455425
http://dx.doi.org/10.1038/srep14953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601089/
https://www.ncbi.nlm.nih.gov/pubmed/26455425
http://dx.doi.org/10.1038/srep14953

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