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Purification of nuclear localization signal-containing proteins and its application to investigation of the mechanisms of the cell division cycle

The GTP bound form of the Ran GTPase (RanGTP) in the nucleus promotes nuclear import of the proteins bearing nuclear localization signals (NLS). When nuclear envelopes break down during mitosis, RanGTP is locally produced around chromosomes and drives the assembly of the spindle early in mitosis and...

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Detalles Bibliográficos
Autores principales: Christodoulou, Andri, Yokoyama, Hideki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601338/
https://www.ncbi.nlm.nih.gov/pubmed/25862163
http://dx.doi.org/10.4161/21541248.2014.978162