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In vivo dynamics of skeletal muscle Dystrophin in zebrafish embryos revealed by improved FRAP analysis
Dystrophin forms an essential link between sarcolemma and cytoskeleton, perturbation of which causes muscular dystrophy. We analysed Dystrophin binding dynamics in vivo for the first time. Within maturing fibres of host zebrafish embryos, our analysis reveals a pool of diffusible Dystrophin and comp...
Autores principales: | Bajanca, Fernanda, Gonzalez-Perez, Vinicio, Gillespie, Sean J, Beley, Cyriaque, Garcia, Luis, Theveneau, Eric, Sear, Richard P, Hughes, Simon M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601390/ https://www.ncbi.nlm.nih.gov/pubmed/26459831 http://dx.doi.org/10.7554/eLife.06541 |
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