Splicing changes in SMA mouse motoneurons and SMN-depleted neuroblastoma cells: Evidence for involvement of splicing regulatory proteins

Spinal Muscular Atrophy (SMA) is caused by deletions or mutations in the Survival Motor Neuron 1 (SMN1) gene. The second gene copy, SMN2, produces some, but not enough, functional SMN protein. SMN is essential to assemble small nuclear ribonucleoproteins (snRNPs) that form the spliceosome. However,...

Descripción completa

Detalles Bibliográficos
Autores principales: Huo, Qing, Kayikci, Melis, Odermatt, Philipp, Meyer, Kathrin, Michels, Olivia, Saxena, Smita, Ule, Jernej, Schümperli, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601534/
https://www.ncbi.nlm.nih.gov/pubmed/25692239
http://dx.doi.org/10.1080/15476286.2014.996494

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601534/
https://www.ncbi.nlm.nih.gov/pubmed/25692239
http://dx.doi.org/10.1080/15476286.2014.996494

Ejemplares similares