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Prion aggregate structure in yeast cells is determined by the Hsp104-Hsp110 disaggregase machinery
Prions consist of misfolded proteins that have adopted an infectious amyloid conformation. In vivo, prion biogenesis is intimately associated with the protein quality control machinery. Using electron tomography, we probed the effects of the heat shock protein Hsp70 chaperone system on the structure...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602031/ https://www.ncbi.nlm.nih.gov/pubmed/26438827 http://dx.doi.org/10.1083/jcb.201505104 |