RanGTP aids anaphase entry through Ubr5-mediated protein turnover

RanGTP is known to regulate the spindle assembly checkpoint (SAC), but the underlying molecular mechanism is unclear. BuGZ stabilizes SAC protein Bub3 through direct interaction and facilitates its mitotic function. Here we show that RanGTP promotes the turnover of BuGZ and Bub3 in metaphase, which...

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Detalles Bibliográficos
Autores principales: Jiang, Hao, He, Xiaonan, Feng, Di, Zhu, Xueliang, Zheng, Yixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602037/
https://www.ncbi.nlm.nih.gov/pubmed/26438829
http://dx.doi.org/10.1083/jcb.201503122

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602037/
https://www.ncbi.nlm.nih.gov/pubmed/26438829
http://dx.doi.org/10.1083/jcb.201503122

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