Effect of cAMP signaling on expression of glucocorticoid receptor, Bim and Bad in glucocorticoid-sensitive and resistant leukemic and multiple myeloma cells

Stimulation of cAMP signaling induces apoptosis in glucocorticoid-sensitive and resistant CEM leukemic and MM.1 multiple myeloma cell lines, and this effect is enhanced by dexamethasone in both glucocorticoid-sensitive cell types and in glucocorticoid-resistant CEM cells. Expression of the mRNA for...

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Detalles Bibliográficos
Autores principales: Dong, Hongli, Carlton, Michael E., Lerner, Adam, Epstein, Paul M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602131/
https://www.ncbi.nlm.nih.gov/pubmed/26528184
http://dx.doi.org/10.3389/fphar.2015.00230

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602131/
https://www.ncbi.nlm.nih.gov/pubmed/26528184
http://dx.doi.org/10.3389/fphar.2015.00230

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