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Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system
Although its roles in the vascular space are most well-known, tissue plasminogen activator (tPA) is widely expressed in the developing and adult nervous system, where its activity is believed to be regulated by neuroserpin, a predominantly brain-specific member of the serpin family of protease inhib...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602146/ https://www.ncbi.nlm.nih.gov/pubmed/26528129 http://dx.doi.org/10.3389/fncel.2015.00396 |
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author | Lee, Tet Woo Tsang, Vicky W. K. Birch, Nigel P. |
author_facet | Lee, Tet Woo Tsang, Vicky W. K. Birch, Nigel P. |
author_sort | Lee, Tet Woo |
collection | PubMed |
description | Although its roles in the vascular space are most well-known, tissue plasminogen activator (tPA) is widely expressed in the developing and adult nervous system, where its activity is believed to be regulated by neuroserpin, a predominantly brain-specific member of the serpin family of protease inhibitors. In the normal physiological state, tPA has been shown to play roles in the development and plasticity of the nervous system. Ischemic damage, however, may lead to excess tPA activity in the brain and this is believed to contribute to neurodegeneration. In this article, we briefly review the physiological and pathological roles of tPA in the nervous system, which includes neuronal migration, axonal growth, synaptic plasticity, neuroprotection and neurodegeneration, as well as a contribution to neurological disease. We summarize tPA's multiple mechanisms of action and also highlight the contributions of the inhibitor neuroserpin to these processes. |
format | Online Article Text |
id | pubmed-4602146 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46021462015-11-02 Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system Lee, Tet Woo Tsang, Vicky W. K. Birch, Nigel P. Front Cell Neurosci Neuroscience Although its roles in the vascular space are most well-known, tissue plasminogen activator (tPA) is widely expressed in the developing and adult nervous system, where its activity is believed to be regulated by neuroserpin, a predominantly brain-specific member of the serpin family of protease inhibitors. In the normal physiological state, tPA has been shown to play roles in the development and plasticity of the nervous system. Ischemic damage, however, may lead to excess tPA activity in the brain and this is believed to contribute to neurodegeneration. In this article, we briefly review the physiological and pathological roles of tPA in the nervous system, which includes neuronal migration, axonal growth, synaptic plasticity, neuroprotection and neurodegeneration, as well as a contribution to neurological disease. We summarize tPA's multiple mechanisms of action and also highlight the contributions of the inhibitor neuroserpin to these processes. Frontiers Media S.A. 2015-10-13 /pmc/articles/PMC4602146/ /pubmed/26528129 http://dx.doi.org/10.3389/fncel.2015.00396 Text en Copyright © 2015 Lee, Tsang and Birch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Lee, Tet Woo Tsang, Vicky W. K. Birch, Nigel P. Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
title | Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
title_full | Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
title_fullStr | Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
title_full_unstemmed | Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
title_short | Physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
title_sort | physiological and pathological roles of tissue plasminogen activator and its inhibitor neuroserpin in the nervous system |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602146/ https://www.ncbi.nlm.nih.gov/pubmed/26528129 http://dx.doi.org/10.3389/fncel.2015.00396 |
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