Characterization of plasma protein binding dissociation with online SPE-HPLC

A novel parameter of relative recovery (R(re)) was defined and determined by online SPE-HPLC to characterize plasma protein binding (PPB) kinetics of highly plasma binding drugs. The proportional relationship of R(re) with k(off) of PPB has been established with a new SPE model. A rapid, easy to use...

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Detalles Bibliográficos
Autores principales: Li, Ping, Fan, Yiran, Wang, Yunlong, Lu, Yaxin, Yin, Zheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602217/
https://www.ncbi.nlm.nih.gov/pubmed/26460813
http://dx.doi.org/10.1038/srep14866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602217/
https://www.ncbi.nlm.nih.gov/pubmed/26460813
http://dx.doi.org/10.1038/srep14866

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