The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation

Folate metabolism is central to cell proliferation and a target of commonly used cancer chemotherapeutics. In particular, the mitochondrial folate-coupled metabolism is thought to be important for proliferating cancer cells. The enzyme MTHFD2 in this pathway is highly expressed in human tumors and b...

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Detalles Bibliográficos
Autores principales: Gustafsson Sheppard, Nina, Jarl, Lisa, Mahadessian, Diana, Strittmatter, Laura, Schmidt, Angelika, Madhusudan, Nikhil, Tegnér, Jesper, Lundberg, Emma K., Asplund, Anna, Jain, Mohit, Nilsson, Roland
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602236/
https://www.ncbi.nlm.nih.gov/pubmed/26461067
http://dx.doi.org/10.1038/srep15029

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