Sensitive Determination of Onco-metabolites of D- and L-2-hydroxyglutarate Enantiomers by Chiral Derivatization Combined with Liquid Chromatography/Mass Spectrometry Analysis

2-hydroxyglutarate (2HG) is a potent competitor of α-ketoglutarate (α-KG) and can inhibit multiple α-KG dependent dioxygenases that function on the epigenetic modifications. The accumulation of 2HG contributes to elevated risk of malignant tumors. 2HG carries an asymmetric carbon atom in its carbon...

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Detalles Bibliográficos
Autores principales: Cheng, Qing-Yun, Xiong, Jun, Huang, Wei, Ma, Qin, Ci, Weimin, Feng, Yu-Qi, Yuan, Bi-Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602309/
https://www.ncbi.nlm.nih.gov/pubmed/26458332
http://dx.doi.org/10.1038/srep15217

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4602309/
https://www.ncbi.nlm.nih.gov/pubmed/26458332
http://dx.doi.org/10.1038/srep15217

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