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Bach1 deficiency reduces severity of osteoarthritis through upregulation of heme oxygenase-1
INTRODUCTION: BTB and CNC homology 1 (Bach1) is a transcriptional repressor of Heme oxygenase-1 (HO-1), which is cytoprotective through its antioxidant effects. The objective of this study was to define the role of Bach1 in cartilage homeostasis and osteoarthritis (OA) development using in vitro mod...
Autores principales: | Takada, Tsuyoshi, Miyaki, Shigeru, Ishitobi, Hiroyuki, Hirai, Yuya, Nakasa, Tomoyuki, Igarashi, Kazuhiko, Lotz, Martin K., Ochi, Mitsuo |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603301/ https://www.ncbi.nlm.nih.gov/pubmed/26458773 http://dx.doi.org/10.1186/s13075-015-0792-1 |
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