Cargando…

Blockade of autophagy reduces pancreatic cancer stem cell activity and potentiates the tumoricidal effect of gemcitabine

BACKGROUND: Cancer stem cells (CSCs) are considered responsible for the recurrence and chemoresistance of cancer. Dysregulated autophagy is highly prevalent in many types of cancer including pancreatic cancer and has been implicated in cytoprotection and tumor promotion. This study aimed to investig...

Descripción completa

Detalles Bibliográficos
Autores principales:	Yang, Ming-Chen, Wang, Hao-Chen, Hou, Ya-Chin, Tung, Hui-Ling, Chiu, Tai-Jan, Shan, Yan-Shen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2015
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603764/ https://www.ncbi.nlm.nih.gov/pubmed/26458814 http://dx.doi.org/10.1186/s12943-015-0449-3

Ejemplares similares

Iron Oxide Nanoparticles as Autophagy Intervention Agents Suppress Hepatoma Growth by Enhancing Tumoricidal Autophagy
por: Xie, Yuexia, et al.
Publicado: (2020)

Girdin Knockdown Increases Gemcitabine Chemosensitivity to Pancreatic Cancer by Modulating Autophagy
por: Wang, Sheng, et al.
Publicado: (2021)

Coexpression of CD44-positive/CD133-positive cancer stem cells and CD204-positive tumor-associated macrophages is a predictor of survival in pancreatic ductal adenocarcinoma
por: Hou, Ya-Chin, et al.
Publicado: (2014)

Phosphomimetic Dicer S1016E triggers a switch to glutamine metabolism in gemcitabine-resistant pancreatic cancer
por: Park, Ji Min, et al.
Publicado: (2022)

Reciprocal Complementation of the Tumoricidal Effects of Radiation and Natural Killer Cells
por: Yang, Kai-Lin, et al.
Publicado: (2013)

Tumoricidal activity of human dendritic cells
por: Tel, Jurjen, et al.
Publicado: (2014)

Low CD8(+) T Cell Infiltration and High PD-L1 Expression Are Associated with Level of CD44(+)/CD133(+) Cancer Stem Cells and Predict an Unfavorable Prognosis in Pancreatic Cancer
por: Hou, Ya-Chin, et al.
Publicado: (2019)

Signal regulatory protein alpha blockade potentiates tumoricidal effects of macrophages on gastroenterological neoplastic cells in syngeneic immunocompetent mice
por: Abe, Tomoyuki, et al.
Publicado: (2018)

Blockade of PD-1 and LAG-3 expression on CD8+ T cells promotes the tumoricidal effects of CD8+ T cells
por: Ma, Jiajia, et al.
Publicado: (2023)

Tumoricidal Activity of RNase A and DNase I
por: Patutina, O.A., et al.
Publicado: (2010)

Mechanisms of Arachidonic Acid In Vitro Tumoricidal Impact
por: Tallima, Hatem, et al.
Publicado: (2023)

α, γ-Mangostins Induce Autophagy and Show Synergistic Effect with Gemcitabine in Pancreatic Cancer Cell Lines
por: Kim, Myoungjae, et al.
Publicado: (2017)

Antibody blockade of semaphorin 4D breaks down barriers to enhance tumoricidal immune infiltration and supports rational immunotherapy combinations
por: Evans, Elizabeth E, et al.
Publicado: (2015)

Shrimp miR-965 transfers tumoricidal mitochondria
por: Kim, Hyueyun, et al.
Publicado: (2022)

Is gemcitabine (GEM)-based combination therapy good for the treatment of advanced pancreatic cancer?
por: Hao, Fulong, et al.
Publicado: (2023)

Tumoricidal Activity of Simvastatin in Synergy with RhoA Inactivation in Antimigration of Clear Cell Renal Cell Carcinoma Cells
por: Lee, Yuan-Chii Gladys, et al.
Publicado: (2023)

Elevated Serum Interleukin-8 Level Correlates with Cancer-Related Cachexia and Sarcopenia: An Indicator for Pancreatic Cancer Outcomes
por: Hou, Ya-Chin, et al.
Publicado: (2018)

PRRX1/FOXM1 reduces gemcitabin-induced cytotoxicity by regulating autophagy in bladder cancer
por: Huang, Xixi, et al.
Publicado: (2022)

HAMLET, a tumoricidal molecular complex from human milk
por: Svanborg, C, et al.
Publicado: (2009)

Alvaxanthone, a Thymidylate Synthase Inhibitor with Nematocidal and Tumoricidal Activities
por: Maj, Piotr, et al.
Publicado: (2020)

Discovery of tumoricidal DNA oligonucleotides by response-directed in vitro evolution
por: Mamet, Noam, et al.
Publicado: (2020)

Vandetanib alters the tumoricidal capacity of human breast cancer stem cells via inhibiting vasculogenic capacity
por: Haiaty, Sanya, et al.
Publicado: (2023)

Downregulation of ASPP2 in pancreatic cancer cells contributes to increased resistance to gemcitabine through autophagy activation
por: Song, Bin, et al.
Publicado: (2015)

4-Acetylantroquinonol B enhances cell death and inhibits autophagy by downregulating the PI3K/Akt/MDR1 pathway in gemcitabine-resistant pancreatic cancer cells
por: Chen, Ying-Yin, et al.
Publicado: (2022)

Pancreatic stellate cells activated by mutant KRAS-mediated PAI-1 upregulation foster pancreatic cancer progression via IL-8
por: Wang, Hao-Chen, et al.
Publicado: (2019)

Apigenin Increases SHIP-1 Expression, Promotes Tumoricidal Macrophages and Anti-Tumor Immune Responses in Murine Pancreatic Cancer
por: Villalobos-Ayala, Krystal, et al.
Publicado: (2020)

Curcumin Improves the Tumoricidal Effect of Mitomycin C by Suppressing ABCG2 Expression in Stem Cell-Like Breast Cancer Cells
por: Zhou, Qianmei, et al.
Publicado: (2015)

Cytosolic 5′-nucleotidase 1A is overexpressed in pancreatic cancer and mediates gemcitabine resistance by reducing intracellular gemcitabine metabolites
por: Patzak, Melanie S., et al.
Publicado: (2019)

Injectable pH Thermo-Responsive Hydrogel Scaffold for Tumoricidal Neural Stem Cell Therapy for Glioblastoma Multiforme
por: King, Jasmine L., et al.
Publicado: (2022)

Pancreatic Cancer Chemoresistance to Gemcitabine
por: Amrutkar, Manoj, et al.
Publicado: (2017)

TNNC1 Reduced Gemcitabine Sensitivity of Nonsmall-Cell Lung Cancer by Increasing Autophagy
por: Ye, Xian, et al.
Publicado: (2020)

Stimulatory effect of vitamin A on tumoricidal activity of rat alveolar macrophages.
por: Tachibana, K., et al.
Publicado: (1984)

Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells
por: Stary, Georg, et al.
Publicado: (2007)

Evidence for a gamma-interferon receptor that regulates macrophage tumoricidal activity
Publicado: (1984)

A MCP1 fusokine with CCR2-specific tumoricidal activity
por: Rafei, Moutih, et al.
Publicado: (2011)

Suppression by Interleukin 4 of Activation of Human Blood Monocytes to the Tumoricidal State
por: Nishioka, Yasuhiko, et al.
Publicado: (1990)

Multifunctional silica nanocomposites prime tumoricidal immunity for efficient cancer immunotherapy
por: Yang, Linnan, et al.
Publicado: (2021)

Breast Cancer Tumor Microenvironment and Molecular Aberrations Hijack Tumoricidal Immunity
por: Lin, Huey-Jen, et al.
Publicado: (2022)

In situ expansion and reprogramming of Kupffer cells elicit potent tumoricidal immunity against liver metastasis
por: Liu, Wei, et al.
Publicado: (2023)

Up‐regulation of glycolysis promotes the stemness and EMT phenotypes in gemcitabine‐resistant pancreatic cancer cells
por: Zhao, Hengqiang, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_508qpd5203h1r5fk7qh0bqoc3n