Oseltamivir Population Pharmacokinetics in the Ferret: Model Application for Pharmacokinetic/Pharmacodynamic Study Design

The ferret is a suitable small animal model for preclinical evaluation of efficacy of antiviral drugs against various influenza strains, including highly pathogenic H5N1 viruses. Rigorous pharmacokinetics/pharmacodynamics (PK/PD) assessment of ferret data has not been conducted, perhaps due to insuf...

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Detalles Bibliográficos
Autores principales: Reddy, Micaela B., Yang, Kuo-Hsiung, Rao, Gauri, Rayner, Craig R., Nie, Jing, Pamulapati, Chandrasena, Marathe, Bindumadhav M., Forrest, Alan, Govorkova, Elena A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603953/
https://www.ncbi.nlm.nih.gov/pubmed/26460484
http://dx.doi.org/10.1371/journal.pone.0138069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603953/
https://www.ncbi.nlm.nih.gov/pubmed/26460484
http://dx.doi.org/10.1371/journal.pone.0138069

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