mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction upon 4E-BP1 dephosphorylation

The mammalian target of rapamycin (mTOR) is commonly activated in colon cancer. mTOR complex 1 (mTORC1) is a major downstream target of the PI3K/ATK pathway and activates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. Rapamycin analogs Everolimus and...

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Detalles Bibliográficos
Autores principales: He, Kan, Zheng, Xingnan, Li, Mei, Zhang, Lin, Yu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603992/
https://www.ncbi.nlm.nih.gov/pubmed/25867072
http://dx.doi.org/10.1038/onc.2015.79

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603992/
https://www.ncbi.nlm.nih.gov/pubmed/25867072
http://dx.doi.org/10.1038/onc.2015.79

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