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mTOR inhibitors induce apoptosis in colon cancer cells via CHOP-dependent DR5 induction upon 4E-BP1 dephosphorylation

The mammalian target of rapamycin (mTOR) is commonly activated in colon cancer. mTOR complex 1 (mTORC1) is a major downstream target of the PI3K/ATK pathway and activates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. Rapamycin analogs Everolimus and...

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Detalles Bibliográficos
Autores principales:	He, Kan, Zheng, Xingnan, Li, Mei, Zhang, Lin, Yu, Jian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4603992/ https://www.ncbi.nlm.nih.gov/pubmed/25867072 http://dx.doi.org/10.1038/onc.2015.79

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