Kelch Domain of Gigaxonin Interacts with Intermediate Filament Proteins Affected in Giant Axonal Neuropathy

Patients with giant axonal neuropathy (GAN) show progressive loss of motor and sensory function starting in childhood and typically live for less than 30 years. GAN is caused by autosomal recessive mutations leading to low levels of gigaxonin (GIG), a ubiquitously-expressed BTB/Kelch cytoplasmic pro...

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Detalles Bibliográficos
Autores principales: Johnson-Kerner, Bethany L., Garcia Diaz, Alejandro, Ekins, Sean, Wichterle, Hynek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604155/
https://www.ncbi.nlm.nih.gov/pubmed/26460568
http://dx.doi.org/10.1371/journal.pone.0140157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604155/
https://www.ncbi.nlm.nih.gov/pubmed/26460568
http://dx.doi.org/10.1371/journal.pone.0140157

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