A majority of m(6)A residues are in the last exons, allowing the potential for 3′ UTR regulation

We adapted UV CLIP (cross-linking immunoprecipitation) to accurately locate tens of thousands of m(6)A residues in mammalian mRNA with single-nucleotide resolution. More than 70% of these residues are present in the 3′-most (last) exons, with a very sharp rise (sixfold) within 150–400 nucleotides of...

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Detalles Bibliográficos
Autores principales: Ke, Shengdong, Alemu, Endalkachew A., Mertens, Claudia, Gantman, Emily Conn, Fak, John J., Mele, Aldo, Haripal, Bhagwattie, Zucker-Scharff, Ilana, Moore, Michael J., Park, Christopher Y., Vågbø, Cathrine Broberg, Kusśnierczyk, Anna, Klungland, Arne, Darnell, James E., Darnell, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604345/
https://www.ncbi.nlm.nih.gov/pubmed/26404942
http://dx.doi.org/10.1101/gad.269415.115

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604345/
https://www.ncbi.nlm.nih.gov/pubmed/26404942
http://dx.doi.org/10.1101/gad.269415.115

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