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Functional relevance of “seed” and “non-seed” sequences in microRNA-mediated promotion of C. elegans developmental progression
The founding heterochronic microRNAs, lin-4 and let-7, together with their validated targets and well-characterized phenotypes in C. elegans, offer an opportunity to test functionality of microRNAs in a developmental context. In this study, we defined sequence requirements at the microRNA level for...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604436/ https://www.ncbi.nlm.nih.gov/pubmed/26385508 http://dx.doi.org/10.1261/rna.053793.115 |