The 9p21.3 risk of childhood acute lymphoblastic leukaemia is explained by a rare high-impact variant in CDKN2A

Genome-wide association studies (GWAS) have provided strong evidence for inherited predisposition to childhood acute lymphoblastic leukaemia (ALL) identifying a number of risk loci. We have previously shown common SNPs at 9p21.3 influence ALL risk. These SNP associations are generally not themselves...

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Detalles Bibliográficos
Autores principales: Vijayakrishnan, Jayaram, Henrion, Marc, Moorman, Anthony V., Fiege, Bettina, Kumar, Rajiv, Inacio da Silva Filho, Miguel, Holroyd, Amy, Koehler, Rolf, Thomsen, Hauke, Irving, Julie A., Allan, James M., Lightfoot, Tracy, Roman, Eve, Kinsey, Sally E., Sheridan, Eamonn, Thompson, Pamela D., Hoffmann, Per, Nöthen, Markus M., Mühleisen, Thomas W., Eisele, Lewin, Bartram, Claus R., Schrappe, Martin, Greaves, Mel, Hemminki, Kari, Harrison, Christine J., Stanulla, Martin, Houlston, Richard S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604478/
https://www.ncbi.nlm.nih.gov/pubmed/26463672
http://dx.doi.org/10.1038/srep15065

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604478/
https://www.ncbi.nlm.nih.gov/pubmed/26463672
http://dx.doi.org/10.1038/srep15065

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