Cargando…
Enhanced regeneration and functional recovery after spinal root avulsion by manipulation of the proteoglycan receptor PTPσ
Following root avulsion, spinal nerves are physically disconnected from the spinal cord. Severe motoneuron death and inefficient axon regeneration often result in devastating motor dysfunction. Newly formed axons need to extend through inhibitory scar tissue at the CNS-PNS transitional zone before e...
Autores principales: | Li, Heng, Wong, Connie, Li, Wen, Ruven, Carolin, He, Liumin, Wu, Xiaoli, Lang, Bradley T., Silver, Jerry, Wu, Wutian |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604492/ https://www.ncbi.nlm.nih.gov/pubmed/26464223 http://dx.doi.org/10.1038/srep14923 |
Ejemplares similares
-
Modulation of proteoglycan receptor PTPσ enhances MMP-2 activity to promote recovery from multiple sclerosis
por: Luo, Fucheng, et al.
Publicado: (2018) -
Spinal root avulsion: an excellent model for studying motoneuron degeneration and regeneration after severe axonal injury
por: Ruven, Carolin, et al.
Publicado: (2014) -
Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury
por: Lang, BT, et al.
Publicado: (2014) -
Perturbing chondroitin sulfate proteoglycan signaling through LAR and PTPσ receptors promotes a beneficial inflammatory response following spinal cord injury
por: Dyck, Scott, et al.
Publicado: (2018) -
PTPσ inhibitors promote hematopoietic stem cell regeneration
por: Zhang, Yurun, et al.
Publicado: (2019)