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Transient, activity dependent inhibition of transmitter release from low threshold afferents mediated by GABA(A) receptors in spinal cord lamina III/IV

BACKGROUND: Presynaptic GABA(A) receptors (GABA(A)Rs) located on central terminals of low threshold afferent fibers are thought to be involved in the processing of touch and possibly in the generation of tactile allodynia in chronic pain. These GABA(A)Rs mediate primary afferent depolarization (PAD)...

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Detalles Bibliográficos
Autores principales: Betelli, Chiara, MacDermott, Amy B., Bardoni, Rita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605127/
https://www.ncbi.nlm.nih.gov/pubmed/26463733
http://dx.doi.org/10.1186/s12990-015-0067-5