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NUFIP and the HSP90/R2TP chaperone bind the SMN complex and facilitate assembly of U4-specific proteins
The Sm proteins are loaded on snRNAs by the SMN complex, but how snRNP-specific proteins are assembled remains poorly characterized. U4 snRNP and box C/D snoRNPs have structural similarities. They both contain the 15.5K and proteins with NOP domains (PRP31 for U4, NOP56/58 for snoRNPs). Biogenesis o...
Autores principales: | Bizarro, Jonathan, Dodré, Maxime, Huttin, Alexandra, Charpentier, Bruno, Schlotter, Florence, Branlant, Christiane, Verheggen, Céline, Massenet, Séverine, Bertrand, Edouard |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605303/ https://www.ncbi.nlm.nih.gov/pubmed/26275778 http://dx.doi.org/10.1093/nar/gkv809 |
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