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Nucleolin stabilizes G-quadruplex structures folded by the LTR promoter and silences HIV-1 viral transcription
Folding of the LTR promoter into dynamic G-quadruplex conformations has been shown to suppress its transcriptional activity in HIV-1. Here we sought to identify the proteins that control the folding of this region of proviral genome by inducing/stabilizing G-quadruplex structures. The implementation...
Autores principales: | Tosoni, Elena, Frasson, Ilaria, Scalabrin, Matteo, Perrone, Rosalba, Butovskaya, Elena, Nadai, Matteo, Palù, Giorgio, Fabris, Dan, Richter, Sara N. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605322/ https://www.ncbi.nlm.nih.gov/pubmed/26354862 http://dx.doi.org/10.1093/nar/gkv897 |
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