The rates of the major steps in the molecular mechanism of RNase H1-dependent antisense oligonucleotide induced degradation of RNA

Antisense oligonucleotides (ASOs) are most commonly designed to reduce targeted RNA via RNase H1-dependent degradation, however kinetic parameters for ASO-mediated targeting and subsequent cleavage and degradation of RNA in living cells are poorly understood. In this manuscript we use an inducible m...

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Detalles Bibliográficos
Autores principales: Vickers, Timothy A., Crooke, Stanley T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605327/
https://www.ncbi.nlm.nih.gov/pubmed/26384424
http://dx.doi.org/10.1093/nar/gkv920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605327/
https://www.ncbi.nlm.nih.gov/pubmed/26384424
http://dx.doi.org/10.1093/nar/gkv920

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