Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

One of the major obstacles to the pharmaceutical success of oligonucleotide therapeutics (ONTs) is efficient delivery from the point of injection to the intracellular setting where functional gene silencing occurs. In particular, a significant fraction of internalized ONTs are nonproductively seques...

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Detalles Bibliográficos
Autores principales: Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605330/
https://www.ncbi.nlm.nih.gov/pubmed/26400165
http://dx.doi.org/10.1093/nar/gkv942

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605330/
https://www.ncbi.nlm.nih.gov/pubmed/26400165
http://dx.doi.org/10.1093/nar/gkv942

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