Cargando…

Guanabenz (Wytensin™) selectively enhances uptake and efficacy of hydrophobically modified siRNAs

One of the major obstacles to the pharmaceutical success of oligonucleotide therapeutics (ONTs) is efficient delivery from the point of injection to the intracellular setting where functional gene silencing occurs. In particular, a significant fraction of internalized ONTs are nonproductively seques...

Descripción completa

Detalles Bibliográficos
Autores principales:	Osborn, Maire F., Alterman, Julia F., Nikan, Mehran, Cao, Hong, Didiot, Marie C., Hassler, Matthew R., Coles, Andrew H., Khvorova, Anastasia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605330/ https://www.ncbi.nlm.nih.gov/pubmed/26400165 http://dx.doi.org/10.1093/nar/gkv942

Ejemplares similares

Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways
por: Osborn, Maire F, et al.
Publicado: (2019)

Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo
por: Biscans, Annabelle, et al.
Publicado: (2019)

Visualization of self-delivering hydrophobically modified siRNA cellular internalization
por: Ly, Socheata, et al.
Publicado: (2017)

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo
por: Hassler, Matthew R, et al.
Publicado: (2018)

5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo
por: Haraszti, Reka A., et al.
Publicado: (2017)

The chemical structure and phosphorothioate content of hydrophobically modified siRNAs impact extrahepatic distribution and efficacy
por: Biscans, Annabelle, et al.
Publicado: (2020)

Hydrophobically Modified siRNAs Silence Huntingtin mRNA in Primary Neurons and Mouse Brain
por: Alterman, Julia F, et al.
Publicado: (2015)

Structurally constrained phosphonate internucleotide linkage impacts oligonucleotide-enzyme interaction, and modulates siRNA activity and allele specificity
por: Yamada, Ken, et al.
Publicado: (2021)

Docosahexaenoic Acid Conjugation Enhances Distribution and Safety of siRNA upon Local Administration in Mouse Brain
por: Nikan, Mehran, et al.
Publicado: (2016)

Generation and validation of structurally defined antibody–siRNA conjugates
por: Nanna, Alex R, et al.
Publicado: (2020)

Cytosolic delivery of siRNA by ultra-high affinity dsRNA binding proteins
por: Yang, Nicole J., et al.
Publicado: (2017)

Identification of metabolically stable 5′-phosphate analogs that support single-stranded siRNA activity
por: Prakash, Thazha P., et al.
Publicado: (2015)

Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc–siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5′-exonuclease
por: Kumar, Pawan, et al.
Publicado: (2020)

Safety evaluation of 2′-deoxy-2′-fluoro nucleotides in GalNAc-siRNA conjugates
por: Janas, Maja M, et al.
Publicado: (2019)

Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
por: Nair, Jayaprakash K., et al.
Publicado: (2017)

Targeted delivery to macrophages and dendritic cells by chemically modified mannose ligand-conjugated siRNA
por: Uehara, Keiji, et al.
Publicado: (2022)

Targeted delivery and enhanced gene-silencing activity of centrally modified folic acid–siRNA conjugates
por: Salim, Lidya, et al.
Publicado: (2020)

Structural basis for the synergy of 4′- and 2′-modifications on siRNA nuclease resistance, thermal stability and RNAi activity
por: Harp, Joel M, et al.
Publicado: (2018)

Synthesis, chirality-dependent conformational and biological properties of siRNAs containing 5′-(R)- and 5′-(S)-C-methyl-guanosine
por: Mikami, Atsushi, et al.
Publicado: (2020)

From bench to bedside: Improving the clinical safety of GalNAc–siRNA conjugates using seed-pairing destabilization
por: Schlegel, Mark K, et al.
Publicado: (2022)

Overcoming GNA/RNA base-pairing limitations using isonucleotides improves the pharmacodynamic activity of ESC+ GalNAc-siRNAs
por: Schlegel, Mark K, et al.
Publicado: (2021)

The siRNA suppressor RTL1 is redox-regulated through glutathionylation of a conserved cysteine in the double-stranded-RNA-binding domain
por: Charbonnel, Cyril, et al.
Publicado: (2017)

siRNAs containing 2′-fluorinated Northern-methanocarbacyclic (2′-F-NMC) nucleotides: in vitro and in vivo RNAi activity and inability of mitochondrial polymerases to incorporate 2′-F-NMC NTPs
por: Akabane-Nakata, Masaaki, et al.
Publicado: (2021)

Conjugation of hydrophobic moieties enhances potency of antisense oligonucleotides in the muscle of rodents and non-human primates
por: Østergaard, Michael E, et al.
Publicado: (2019)

Enzymatic synthesis of hypermodified DNA polymers for sequence-specific display of four different hydrophobic groups
por: Ondruš, Marek, et al.
Publicado: (2020)

Nascent β-Hairpin Formation of a Natively Unfolded Peptide Reveals the Role of Hydrophobic Contacts
por: Chen, Wei, et al.
Publicado: (2015)

2′-O-Methyl at 20-mer Guide Strand 3′ Termini May Negatively Affect Target Silencing Activity of Fully Chemically Modified siRNA
por: Davis, Sarah M., et al.
Publicado: (2020)

PK-modifying anchors significantly alter clearance kinetics, tissue distribution, and efficacy of therapeutics siRNAs
por: Godinho, Bruno M.D.C., et al.
Publicado: (2022)

A novel siRNA–gemcitabine construct as a potential therapeutic for treatment of pancreatic cancer
por: Simonenko, Vera, et al.
Publicado: (2020)

Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts
por: Shin, Minwook, et al.
Publicado: (2022)

Structure of 5-hydroxymethylcytosine-specific restriction enzyme, AbaSI, in complex with DNA
por: Horton, John R., et al.
Publicado: (2014)

Conformations of Flanking Bases in HIV-1 RNA DIS Kissing Complexes Studied by Molecular Dynamics
por: Réblová, Kamila, et al.
Publicado: (2007)

Components of variance in transcriptomics based on electrophoretic separation of cDNA fragments (cDNA-AFLP)
por: Weiberg, Arne, et al.
Publicado: (2009)

RNA pseudoknots
por: Westhof, Eric, et al.
Publicado: (1992)

Isometric artifacts from polymerase chain reaction‐massively parallel sequencing analysis of short tandem repeat loci: An emerging issue from a new technology?
por: Zupanič Pajnič, Irena, et al.
Publicado: (2022)

Trigger-helix folding pathway and SI3 mediate catalysis and hairpin-stabilized pausing by Escherichia coli RNA polymerase
por: Windgassen, Tricia A., et al.
Publicado: (2014)

Comparative route of administration studies using therapeutic siRNAs show widespread gene modulation in Dorset sheep
por: Ferguson, Chantal M., et al.
Publicado: (2021)

Chemical engineering of therapeutic siRNAs for allele-specific gene silencing in Huntington’s disease models
por: Conroy, Faith, et al.
Publicado: (2022)

Single-Stranded Phosphorothioated Regions Enhance Cellular Uptake of Cholesterol-Conjugated siRNA but Not Silencing Efficacy
por: Ly, Socheata, et al.
Publicado: (2020)

Differential uptake, kinetics and mechanisms of intracellular trafficking of next-generation antisense oligonucleotides across human cancer cell lines
por: Linnane, Emily, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_52gsmscm8ms4lnn3l9v1onhrs3