Cargando…

A Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities

GTPases play a major role in various cellular functions such as cell signaling, cell proliferation, cell differentiation, cytoskeleton modulation, and cell motility. Deregulation or mutation of these proteins has considerable consequences resulting in multiple pathological conditions. Targeting GTPa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mondal, Subhanjan, Hsiao, Kevin, Goueli, Said A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc. 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605356/ https://www.ncbi.nlm.nih.gov/pubmed/26167953 http://dx.doi.org/10.1089/adt.2015.643

Ejemplares similares

Activation of G Proteins by Guanine Nucleotide Exchange Factors Relies on GTPase Activity
por: Stanley, Rob J., et al.
Publicado: (2016)

Utility of Bioluminescent Homogeneous Nucleotide Detection Assays in Measuring Activities of Nucleotide-Sugar Dependent Glycosyltransferases and Studying Their Inhibitors
por: Engel, Laurie, et al.
Publicado: (2021)

In vitro fluorescence assay to measure GDP/GTP exchange of guanine nucleotide exchange factors of Rho family GTPases
por: Blaise, Alyssa M, et al.
Publicado: (2021)

The Guanine Nucleotide Exchange Factor Tiam1 Affects Neuronal Morphology; Opposing Roles for the Small GTPases Rac and Rho
por: van Leeuwen, Frank N., et al.
Publicado: (1997)

Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase
por: Mahajan, Divyanshu, et al.
Publicado: (2013)

High throughput bioluminescent assay to characterize and monitor the activity of SARS-CoV-2 methyltransferases
por: Hsiao, Kevin, et al.
Publicado: (2022)

Opposing roles of hematopoietic-specific small GTPase Rac2 and the guanine nucleotide exchange factor Vav1 in osteoclast differentiation
por: Kang, In Soon, et al.
Publicado: (2020)

Corrigendum: Mammalian Mon2/Ysl2 regulates endosome-to-Golgi trafficking but possesses no guanine nucleotide exchange activity toward Arl1 GTPase
por: Mahajan, Divyanshu, et al.
Publicado: (2016)

A homogeneous bioluminescent immunoassay to probe cellular signaling pathway regulation
por: Hwang, Byounghoon (Brian), et al.
Publicado: (2020)

Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases
por: Lee, Chan-Soo, et al.
Publicado: (2010)

Influence of simulated microgravity on the activation of the small GTPase Rho involved in cytoskeletal formation – molecular cloning and sequencing of bovine leukemia-associated guanine nucleotide exchange factor
por: Higashibata, Akira, et al.
Publicado: (2006)

Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport
Publicado: (1995)

Modeling the dynamic behaviors of the COPI vesicle formation regulators, the small GTPase Arf1 and its activating Sec7 guanine nucleotide exchange factor GBF1 on Golgi membranes
por: Sager, Garrett, et al.
Publicado: (2021)

The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
por: Chang, Leo, et al.
Publicado: (2015)

Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO
por: Rafiq, Nisha Bte Mohd, et al.
Publicado: (2017)

RHO to the DOCK for GDP disembarking: Structural insights into the DOCK GTPase nucleotide exchange factors
por: Thompson, Andrew P., et al.
Publicado: (2021)

Altered Conformational Landscape upon Sensing Guanine Nucleotides in a Disease Mutant of Elongation Factor-like 1 (EFL1) GTPase
por: Pérez-Juárez, Jesús, et al.
Publicado: (2022)

Comprehensive behavioral analysis of mice deficient in Rapgef2 and Rapgef6, a subfamily of guanine nucleotide exchange factors for Rap small GTPases possessing the Ras/Rap-associating domain
por: Maeta, Kazuhiro, et al.
Publicado: (2018)

Nucleotide Binding Switches the Information Flow in Ras GTPases
por: Raimondi, Francesco, et al.
Publicado: (2011)

BuGZ exhibits guanine nucleotide exchange factor activity toward tubulin
por: Yon, Wesley J., et al.
Publicado: (2023)

Extraction of active RhoGTPases by RhoGDI regulates spatiotemporal patterning of RhoGTPases
por: Golding, Adriana E, et al.
Publicado: (2019)

The many faces of the guanine-nucleotide exchange factor trio
por: van Rijssel, Jos, et al.
Publicado: (2012)

Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors
por: Malaby, Andrew W., et al.
Publicado: (2017)

The Guanine Nucleotide Exchange Factor ARNO mediates the activation of ARF and phospholipase D by insulin
por: Li, Hai-Sheng, et al.
Publicado: (2003)

The guanine nucleotide exchange factor, Spata13, influences social behaviour and nocturnal activity
por: Bourbia, Nora, et al.
Publicado: (2019)

The substrate specificity of the human TRAPPII complex’s Rab-guanine nucleotide exchange factor activity
por: Jenkins, Meredith L., et al.
Publicado: (2020)

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro
por: Koch, Daniel, et al.
Publicado: (2023)

Mycobacterium Fluoroquinolone Resistance Protein D (MfpD), a GTPase-Activating Protein of GTPase MfpB, Is Involved in Fluoroquinolones Potency
por: Huang, Yu, et al.
Publicado: (2022)

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation
por: Langemeyer, Lars, et al.
Publicado: (2014)

Identification of a Rab GTPase-activating protein cascade that controls recycling of the Rab5 GTPase Vps21 from the vacuole
por: Rana, Meenakshi, et al.
Publicado: (2015)

Anchored Protein Kinase A Recruitment of Active Rac GTPase
por: Logue, Jeremy S., et al.
Publicado: (2011)

Function of Rho GTPase Activating Protein 11A in Tumors
por: Zhou, Hui-Nian, et al.
Publicado: (2018)

The role of GTPase-activating protein ARHGAP26 in human cancers
por: Zhang, Lingye, et al.
Publicado: (2021)

Activation of the Small G Protein Arf6 by Dynamin2 through Guanine Nucleotide Exchange Factors in Endocytosis
por: Okada, Risa, et al.
Publicado: (2015)

The TRAPP complexes: oligomeric exchange factors that activate the small GTPases Rab1 and Rab11
por: Galindo, Antonio, et al.
Publicado: (2022)

Trapp Stimulates Guanine Nucleotide Exchange on Ypt1p
por: Wang, Wei, et al.
Publicado: (2000)

Scambio, a novel guanine nucleotide exchange factor for Rho
por: Curtis, Christina, et al.
Publicado: (2004)

The Minimal Autoinhibited Unit of the Guanine Nucleotide Exchange Factor Intersectin
por: Ahmad, K. Farid, et al.
Publicado: (2010)

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes
por: Randazzo, Paul A, et al.
Publicado: (2014)

Structural biology of DOCK‐family guanine nucleotide exchange factors
por: Boland, Andreas, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_kv4v3qed7h3qs9us8pvfgi7d88