Disruption of Annexin II /p11 Interaction Suppresses Leukemia Cell Binding, Homing and Engraftment, and Sensitizes the Leukemia Cells to Chemotherapy

The bone marrow microenvironment plays an important role in acute lymphoblastic leukemia (ALL) cell proliferation, maintenance, and resistance to chemotherapy. Annexin II (ANX2) is abundantly expressed on bone marrow cells and complexes with p11 to form ANX2/p11-hetero-tetramer (ANX2T). We present e...

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Detalles Bibliográficos
Autores principales: Gopalakrishnapillai, Anilkumar, Kolb, E. Anders, Dhanan, Priyanka, Mason, Robert W., Napper, Andrew, Barwe, Sonali P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605480/
https://www.ncbi.nlm.nih.gov/pubmed/26465153
http://dx.doi.org/10.1371/journal.pone.0140564

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605480/
https://www.ncbi.nlm.nih.gov/pubmed/26465153
http://dx.doi.org/10.1371/journal.pone.0140564

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