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The Characteristics and Regulatory Mechanisms of Superoxide Generation from eNOS Reductase Domain

In addition to superoxide (O(2) (.-)) generation from nitric oxide synthase (NOS) oxygenase domain, a new O(2) (.-) generation site has been identified in the reductase domain of inducible NOS (iNOS) and neuronal NOS (nNOS). Cysteine S-glutathionylation in eNOS reductase domain also induces O(2) (.-...

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Detalles Bibliográficos
Autores principales: Peng, Hu, Zhuang, Yugang, Chen, Yuanzhuo, Rizzo, Alicia N., Chen, Weiguo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605588/
https://www.ncbi.nlm.nih.gov/pubmed/26465144
http://dx.doi.org/10.1371/journal.pone.0140365