Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice

The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRL(lpr) mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRL(...

Descripción completa

Detalles Bibliográficos
Autores principales: Schirmer, Bastian, Wedekind, Dirk, Glage, Silke, Neumann, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605611/
https://www.ncbi.nlm.nih.gov/pubmed/26465326
http://dx.doi.org/10.1371/journal.pone.0140173

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605611/
https://www.ncbi.nlm.nih.gov/pubmed/26465326
http://dx.doi.org/10.1371/journal.pone.0140173

Ejemplares similares