Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice

The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRL(lpr) mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRL(...

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Detalles Bibliográficos
Autores principales: Schirmer, Bastian, Wedekind, Dirk, Glage, Silke, Neumann, Detlef
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605611/
https://www.ncbi.nlm.nih.gov/pubmed/26465326
http://dx.doi.org/10.1371/journal.pone.0140173
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author Schirmer, Bastian
Wedekind, Dirk
Glage, Silke
Neumann, Detlef
author_facet Schirmer, Bastian
Wedekind, Dirk
Glage, Silke
Neumann, Detlef
author_sort Schirmer, Bastian
collection PubMed
description The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRL(lpr) mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRL(lpr) mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time, lymphadenopathy, constitutive interferon-γ production, and frequency of CD3(+)B220(+) abnormal T cells were without differences. We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis.
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spelling pubmed-46056112015-10-29 Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice Schirmer, Bastian Wedekind, Dirk Glage, Silke Neumann, Detlef PLoS One Research Article The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRL(lpr) mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRL(lpr) mice show reduced signs of renal pathogenesis, while other parameters such as mean survival time, lymphadenopathy, constitutive interferon-γ production, and frequency of CD3(+)B220(+) abnormal T cells were without differences. We conclude that in the systemic lupus erythematosus syndrom IL-18 is involved specifically in the renal pathogenesis. Public Library of Science 2015-10-14 /pmc/articles/PMC4605611/ /pubmed/26465326 http://dx.doi.org/10.1371/journal.pone.0140173 Text en © 2015 Schirmer et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Schirmer, Bastian
Wedekind, Dirk
Glage, Silke
Neumann, Detlef
Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
title Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
title_full Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
title_fullStr Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
title_full_unstemmed Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
title_short Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice
title_sort deletion of il-18 expression ameliorates spontaneous kidney failure in mrl(lpr) mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605611/
https://www.ncbi.nlm.nih.gov/pubmed/26465326
http://dx.doi.org/10.1371/journal.pone.0140173
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