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Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRL(lpr) Mice

The role of IL-18 in the pathogenesis of systemic lupus erythematosus is still not definitively solved. In this study, we generated MRL(lpr) mice, which develop a disease resembling systemic lupus erythematosus, genetically devoid of IL-18 expression. These mice in comparison to IL-18-competent MRL(...

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Detalles Bibliográficos
Autores principales:	Schirmer, Bastian, Wedekind, Dirk, Glage, Silke, Neumann, Detlef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605611/ https://www.ncbi.nlm.nih.gov/pubmed/26465326 http://dx.doi.org/10.1371/journal.pone.0140173

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