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A Genome-Wide Screen for Machinery Involved in Downregulation of MHC Class I by HIV-1 Nef
The HIV-1-encoded protein, Nef, plays a key role in the development of AIDS. One of Nef’s functions is to keep MHC class I off the surface of infected cells, a process that requires the host proteins clathrin and AP-1. To identify other proteins involved in this pathway, we carried out a genome-wide...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4605695/ https://www.ncbi.nlm.nih.gov/pubmed/26466362 http://dx.doi.org/10.1371/journal.pone.0140404 |